The NMR biofluid has proven itself to be extremely useful in biomarker discoveries over the years 5, 6. The metabolomics approach identifies and quantifies metabolites, which are key products to understand the metabolic state of an organism 4. In order to explore a broad biological view of metabolism, Systems Biology has been largely used in the recent years. However, the contribution of unhealthy lifestyle factors to the progression of obesity, along with optimal non-pharmacological treatment strategies, remains to be elucidated. Despite being a multifactorial disease, the mechanisms of the systemic energy imbalance underlying obesity are well explained 3. A sedentary lifestyle together with unhealthy eating habits leads to the onset of noncommunicable diseases (NCDs), such as type 2 diabetes (T2D), cardiovascular diseases (CVDs), and obesity 2. Obesity in childhood and adolescence has been considered one of the most serious public health problems in the world 1. These findings demonstrate the positive effects of CT program without dietary intervention on metabolomic profile, body composition, biochemical markers, and glucose metabolism in overweight and obese adolescents. The metabolic changes were given mainly by changes in the levels of metabolites 2-oxoisocaproate (↓TG), 3-hydroxyisobutyrate (↑CG and ↓TG), glucose (↓TG), glutamine (↓CG and ↑TG) and pyruvate (↓TG). An increase in fat-free mass (FFM) was also observed in the CG. There was a decrease in body weight (BW), body mass index (BMI), waist circumference (WC), % body fat (%BF), fasting glucose, insulin levels, and insulin resistance (IR), by HOMA-IR, in the TG. Metabolomics analyses were conducted using nuclear magnetic resonance spectroscopy ( 1H NMR) in a 600 MHz spectrometer. All assessments were performed pre and post-intervention. The CT was composed by resistance training and aerobic training performed in the same session (~ 60 min), three times a week, for 12 weeks. Thirty-seven adolescents (14.6 ± 1.05 years), of both sexes, were randomly assigned to the control group (CG, n = 19) or the training group (TG, n = 18). We investigated how combined training (CT) without dietary intervention altered the concentrations of serum metabolites, biochemical, anthropometric and functional parameters in overweight and obese adolescents. However, the isolated metabolic changes caused by exercise training without dietary intervention have not yet been established. Exercise training and a healthy diet are the main non-pharmacological strategies for treating chronic conditions, such as obesity and insulin resistance (IR), in adolescents.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |